Wissenschaftliche Daten zu Stammzellen für die Gelenke

Weltweit wurde das regenerative Potenzial von Fettstammzellen bei Gelenkproblemen wie Arthrose und Knorpelschäden in klinischen Studien untersucht. Dabei konnten Forscher bei Patientinnen und Patienten, die wegen Schäden an Knien, Hüften und anderen Gelenken mittels Stammzelltherapie behandelt wurden, eine Verbesserung der Schmerzsymptomatik und Beweglichkeit feststellen.

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Übersicht wissenschaftlicher Studien

• Arthur, A., Zannettino, A., Gronthos, S.: The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. In: J Cell Physiol 218. Nr. 2, Februar 2009, S. 237–245.
• Bansal, H., Comella, K., Leon, J. et al.: Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis. In: J Transl Med 15. Artikelnr. 141, 19. Juni 2017.
• Bui, K.H.-T., Duong, T.D., Nguyen, N.T. et al.: Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study. In: Biomed Res Ther 1. Nr. 1, 2014, S. 2–8.
• Centeno, C.J., Busse, D., Kisiday, J. et al.: Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. In: Pain Physician 11. Nr. 3, Mai–Juni 2008, S. 343–353.
• Centeno, C.J., Busse, D., Kisiday, J. et al.: Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells. In: Med Hypotheses 71. Nr. 6, Dezember 2008, S. 900–908, Epub 10. September 2008.
• Chen, F.H., Tuan, R.S.: Mesenchymal stem cells in arthritic diseases. In: Arthritis Res Ther 10. Artikelnr. 223, Epub 10. Oktober 2008.
• Devine, S.M., Bartholomew, A.M., Mahmud, N. et al.: Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion. In: Exp Hematol 29. Nr. 2, Februar 2001, S. 244–255.
• Diekman, B.O., Guilak, F.: Stem cell-based therapies for osteoarthritis: challenges and opportunities. In: Curr Opin Rheumatol 25. Nr. 1, Januar 2013, S. 119–126.
• Fodor, P.B., Paulseth, S.G.: Adipose derived stromal cell (ADSC) injections for pain management of osteoarthritis in the human knee joint. In: Aesthet Surg J 36. Nr. 2, S. 229–236, Februar 2016, Epub 3. August 2015.
• Garza, J.R., Santa Maria, D., Palomera, T. et al.: Use of autologous adipose-derived stromal vascular fraction to treat osteoarthritis of the knee: a feasibility and safety study. In: J Regen Med 4. Nr. 1, 16. März 2015.
• González, M.A., Gonzalez-Rey, E., Rico, L. et al.: Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. In: Arthritis Rheum 60. Nr. 4, April 2009, S. 1006–1019.
• Jo, C.H., Lee, Y.G., Shin, W.H. et al.: Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. In: Stem Cells 32. Nr. 5, S. 1254–1266, Mai 2014.
• Kasir, R., Vernekar, V.N., Laurencin, C.T.: Regenerative engineering of cartilage using adipose-derived stem cells. In: Regen Eng Transl Med 1. Nr. 1, S. 42–49, 1. Dezember 2015, Epub 30. November 2015.
• Kim, Y.S., Choi, Y.J., Suh, D.S. et al.: Mesenchymal stem cell implantation in osteoarthritic knees: is fibrin glue effective as a scaffold?. In: Am J Sports Med 43. Nr. 1, S. 176–185, Januar 2015, Epub 27. Oktober 2014.
• Koh, Y.-G., Choi, Y.-J.: Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis. In: Knee 19. Nr. 6, Dezember 2012, S. 902–907, Epub 14. Mai 2012.
• Koh, Y.-G., Choi, Y.-J., Kwon, S.-K. et al.: Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis. In: Knee Surg Sports Traumatol Arthrosc. 11. Dezember 2013, Epub vor dem Druck.
• Koh, Y.-G., Jo, S.-B., Kwon, O.-R. et al.: Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. In: Arthroscopy 29. Nr. 4, April 2013, S. 748–755, Epub 29. Januar 2013.
• Koh, Y.G., Choi, Y.J., Kwon, O.R., Kim, Y.S.: Second-look arthroscopic evaluation of cartilage lesions after mesenchymal stem cell implantation in osteoarthritic knees. In: Am J Sports Med 42. Nr. 7, S. 1628–1637, Juli 2014, Epub 17. April 2014.
• Koh, Y.-G., Kwon, O.-R., Kim, Y.-S., Choi, Y.-J.: Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study. In: Arthroscopy 30. Nr. 11, S. 1453–1460, November 2014, Epub 16. August 2014.
• Kuroda, R., Ishida, K., Matsumoto, T. et al.: Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells. In: Osteoarthritis Cartilage 15. Nr. 2, Februar 2007, S. 226–231, Epub 26. September 2006.
• Manferdini, C., Maumus, M., Gabusi, E. et al.: Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E₂. In: Arthritis Rheum 65. Nr. 5, Mai 2013, S. 1271–1281.
• Maumus, M., Manferdini, C., Toupet, K. et al.: Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis. In: Stem Cell Res 11. Nr. 2, September 2013, S. 834–844, Epub 4. Juni 2013.
• Michalek, J., Vrablikova, A., Darinskas, A. et al.: Stromal vascular fraction cell therapy for osteoarthritis in elderly: Multicenter case-control study. In: J Clin Orthop Trauma 11. Nr. 1, Januar–Februar 2019, S. 76–80, Epub 23. November 2018.
• Murphy, M.B., Moncivais, K., Caplan, A.I.: Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. In: Exp Mol Med 45. Nr. 11, Artikelnr. e54, November 2013, Epub 15. November 2013.
• Orozco, L., Munar, A., Soler, R. et al.: Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. In: Transplantation 95. Nr. 12, 27. Juni 2013, S. 1535–1541.
• Pak, J.: Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. In: J Med Case Rep 5. Artikelnr. 296, 7. Juli 2011.
• Pak, J., Lee, J.H., Lee, S.H.: A novel biological approach to treat chondromalacia patellae. In: PLoS One 8. Nr. 5, Artikelnr. e64569, 20. Mai 2013.
• Pak, J., Chang, J.-J., Lee, J.H., Lee, S.H.: Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints. In: BMC Musculoskelet Disord 14. Artikelnr. 337, Epub 1. Dezember 2013.
• Pak, J., Lee, J.H., Lee, S.H.: Regenerative repair of damaged meniscus with autologous adipose tissue-derived stem cells. In: Biomed Res Int 2014. Artikelnr. 436029, Epub 30. Januar 2014.
• Pers, Y.-M., Rackwitz, L., Ferreira, R. et al.: Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial. In: Stem Cells Transl Med 5. Nr. 7, S. 847–856, Juli 2016, Epub 23. Mai 2016.
• Rada, T., Reis, R.L., Gomes, M.E.: Adipose tissue-derived stem cells and their application in bone and cartilage tissue engineering. In: Tissue Eng Part B Rev 15. Nr. 2, Juni 2009, S. 113–125.
• Riester, S.M., Denbeigh, J.M., Lin, Y. et al.: Safety studies for use of adipose tissue-derived mesenchymal stromal/stem cells in a rabbit model for osteoarthritis to support a phase I clinical trial. In: Stem Cells Transl Med. 26. Oktober 2016, Epub vor dem Druck.
• Siennicka, K., Zolocinska, A., Stepien, K. et al.: Adipose-derived cells (stromal vascular fraction) transplanted for orthopedical or neurological purposes: are they safe enough?. In: Stem Cells Int 2016. Artikelnr. 5762916, Epub 6. September 2016.
• Tapp, H., Hanley, E.N. Jr., Patt, J.C., Gruber, H.E.: Adipose-derived stem cells: characterization and current application in orthopaedic tissue repair. In: Exp Biol Med (Maywood) 234. Nr. 1, Januar 2009, S. 1–9.
• ter Huurne, M., Schelbergen, R., Blattes, R. et al.: Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. In: Arthritis Rheum 64. Nr. 11, November 2012, S. 3604–3613.
• Uysal, A.C., Mizuno, H.: Tendon regeneration and repair with adipose derived stem cells. In: Curr Stem Cell Res Ther 5. Nr. 2, Juni 2010, S. 161–167.
• Vangsness, C.T., Farr, J. II., Boyd, J. et al.: Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. In: J Bone Joint Surg Am 96. Nr. 2, 15. Januar 2014, S. 90–98.
• Wakitani, S., Nawata, M., Tensho, K. et al.: Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. In: J Tissue Eng Regen Med 1. Nr. 1, Januar–Februar 2007, S. 74–79.